Pimafucin CAS NO.7681-93-8

Pimaricin, Streptomyces chattanoogensis is an antifungal macrolide polyene that binds to cell membrane sterols. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Investigations show that the compound predominantly binds to the main sterol in fungal membranes, ergosterol, and causes the bacterial membrane to become porous. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Pimarcin has been used as a fungicide in agar media and CYP (cytochrome P450) PimD research proposes that the epoxidiation of Pimaricin occurs through a hydroperoxoferric compound. Pimarcin studies reveal that the regulator PimM binds to eight promoters of Pimarcin genes and its biosynthesis is influenced by a cholesterol oxidase protein encoded by PimE.